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KMID : 0043319930160010001
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Archives of Pharmacal Research
1993 Volume.16 No. 1 p.1 ~ p.5
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S-Nitrosylation of Sulfhydryl Groups in Albumin by Nitrosating Agents
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박진우:Park Jeen-Woo
저자없음:No authors listed
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Abstract
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The reaction of sulfhydryl groups in human serum albumin with bacteriostatic and hypotensive nitrosating agents such as sodium nitroprusside and sodium nitrite has been examined. The low reactivity of sodium nitroprusside to sulfhydryl groups in albumin has been observed and the sterical inaccessibility of this agent to the site which sulfhydryl group resides was implicated. The reaction of sodium nitrite with albumin was highly influenced by pH and little reactivity was observed at physiological pH. On the other hand, the reaction between albumin and S-nitrosoglutathione, an intermediate induced from the reaction of glutathione and nitrosating agents, resulted in the rapid decrease of free sulfhydryl groups in albumin. S-Nitrosylation of the sulfhydryl group by S-nitrosoglutathione and the subsequent production of mixed disulfide is the probable route of modification. In the physiological system, S-nitrosoglutathione may act as an active intermediate in expressing reactivity of nitrosating agents to sulfhydryl groups in albumin.
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